Psora-4| CAS 724709-68-6|DC Chemicals

Cas No.:	724709-68-6
Chemical Name:	7H-Furo[3,2-g][1]benzopyran-7-one,4-(4-phenylbutoxy)-
Synonyms:	7H-Furo[3,2-g][1]benzopyran-7-one,4-(4-phenylbutoxy)-;Psora 4;5-(4-Phenylbutoxy)psoralen;Lopac-P-9872;Psora-4;PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM;4-(4-phenylbutoxy)furo[3,2-g]chromen-7-one
SMILES:	C1C=CC(CCCCOC2C3C=COC=3C=C3OC(C=CC=23)=O)=CC=1
Formula:	C₂₁H₁₈O₄
M.Wt:	334.365226268768
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Psora-4 is a potent and selective Kv1.3 potassium channel blocker with EC50 of 3 nM; shows 17- to 70-fold selectivity for Kv1.3 over closely related Kv1-family channels (Kv1.1, Kv1.2, Kv1.4, and Kv1.7) with the exception of Kv1.5 (EC50, 7.7 nM), and shows no effect on hERG, Kv3.1, the calcium-activated K+ channels (IKCa1, SK1-SK3, and BKCa), or the neuronal NaV1.2 channel; selectively suppresses the proliferation of human and rat myelin-specific effector memory T cells with EC50 of 25 and 60 nM, respectively, without persistently suppressing peripheral blood naive and central memory T cells.

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