Cas No.: | 1894207-44-3 |
Chemical Name: | (S)-2-(((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)amino)propanamide |
Formula: | C17H17F3N2O |
M.Wt: | 322.331 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | KDS2010 (KDS-2010, KDS 2010) is a potent, highly selective, reversible Monoamine oxidase-B (MAO-B) inhibitor with IC50 of 7.6 nM; displays 12,500-fold selectivity over MAO-A; shows a marked enantiomer selectivity (eightfold selectivity) over the (R)-isomer; significantly ameliorates the impairments in spike probability, learning, and memory in APP/PS1 mice, but not by selegiline, also reverses spatial learning and memory impairments in the Morris water maze test. |