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| Cas No.: | 1090893-12-1 |
| Chemical Name: | 2-Octynyladenosine |
| Synonyms: | YT 146;Adenosine, 2-(1-octynyl)-;2-Octynyladenosine;2-(1-Octynyl)adenosine;2-O-Ado;2-(1-octynyl)-adenosine;adenosine, 1-(1-octynyl)-;BDBM50453216;(2R,3R,4S,5R)-2-(6-amino-2-oct-1-ynylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol;Z62954982 |
| SMILES: | O1[C@]([H])(C([H])([H])O[H])[C@]([H])([C@]([H])([C@]1([H])N1C([H])=NC2=C(N([H])[H])N=C(C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])N=C12)O[H])O[H] |
| Formula: | C18H25N5O4 |
| M.Wt: | 375.4222 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Z62954982 is a potent, specific Rac1 inhibitor, reduces the intracellular levels of Rac1-GTP in a concentration-dependent manner with IC50 of 12 uM, 4 times more effective than NSC23766 (IC50=50 uM); causes a concentration-dependent decrease in transendothelial electrical resistance (TER) in both HDMEC and HUVEC. |
| References: | References 1. Zhang XE, et al. PLoS One. 2016 May 17;11(5):e0155490. 2. Lobastova L, et al. Cell Oncol (Dordr). 2017 Feb;40(1):63-76. 3. Yamaguchi N, et al. Sci Rep. 2015 Jan 7;5:7656. 4. Ferri N, et al. J Med Chem. 2009 Jul 23;52(14):4087-90. View Related Products by Target Small GTPase |
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COA
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| 2018-0101 |
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| 2018-0101 |
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| 2018-0101 |
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