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IU1-47

  Cat. No.:  DC23797   Featured
Chemical Structure
670270-31-2
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More than 5000 active chemicals with high quality for research!
Field of application
IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 670270-31-2
Chemical Name: 1-(1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1yl)ethanone
Synonyms: IU1-47;IU1 47;IU147
SMILES: CC1=CC(C(CN2CCCCC2)=O)=C(C)N1C3=CC=C(Cl)C=C3
Formula: C19H23ClN2O
M.Wt: 330.856
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Boselli M, et al. J Biol Chem. 2017 Nov 24;292(47):19209-19225.
Description: IU1-47 is a potent USP14 inhibitor with an IC50 of 0.6 μM. IU1-47 induces tau elimination in cultured neurons[1].
References: [1]. Boselli M, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 Nov 24;292(47):19209-19225.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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