HPI-1| CAS 599150-20-6|DC Chemicals

Cas No.:	599150-20-6
Chemical Name:	2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
Synonyms:	2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline;HPI 1;HPI-1;0130970;2-METHOXYETHYL 1,4,5,6,7,8-HEXAHYDRO-4-(3-HYDROXYPHENYL)-7-(2-METHOXYPHENYL)-2-METHYL-5-OXO-3-QUINOLINECARBOXYLATE;A3094;AC1MFWGY;CHEMBL1243339;MolPort-000-907-696;ST093553;STK403236;SureCN644336
SMILES:	COCCN1C2=C(C(=O)CC(C3C=CC=CC=3OC)C2)C(C2C=CC=C(O)C=2)C=C1C
Formula:	C₂₆H₂₉NO₄
M.Wt:	419.512767553329
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM) without significantly affecting Wnt signaling (IC50>30 uM); suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression; inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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