CYT387 mesylate| CAS 1056636-07-7

Cas No.:	1056636-07-7
Chemical Name:	Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-, methanesulfonate (1:?)
Synonyms:	Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-, methanesulfonate (1:?);CYT 387 Mesylate;CYT-387 Mesylate;CYT387,MsOHsalt;momelotinib Mesylate;CYT387,MsOH salt;CYT387 (Mesylate)
SMILES:	O=C(C1=CC=C(C2=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC=C2)C=C1)NCC#N.O=S(O)(C)=O
Formula:	C₂₄H₂₆N₆O₅S
M.Wt:	510.565443515778
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM; shows significantly less activity against other kinases, including JAK3 (IC50=155 nM); inhibits JAK2V617F (JH1-JH2) withIC50 of 11 nM; inhibits growth of Ba/F3-JAK2V617F and HEL cells (IC50=1500 nM) or Ba/F3-MPLW515L cells (IC50=200 nM). Bone CancerPhase 3 Clinical

MSDS

COA

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2018-0101

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