CARM1-IN-1| CAS 1020399-49-8|DC Chemicals

Cas No.:	1020399-49-8
Chemical Name:	CARM1-IN-1
Synonyms:	CARM1-IN-1;PRMT4/CARM1 Inhibitor
SMILES:	O=C1/C(CN(CC2=CC=CC=C2)C/C1=C\C3=CC=C(O)C(Br)=C3)=C/C4=CC=C(O)C(Br)=C4
Formula:	C₂₆H₂₁Br₂NO₃
M.Wt:	555.257845640183
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

CARM1-IN-1 is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM, exhibits lower or no activity against a panel of different PRMTs or HKMTs (>80-fold over PRMT1 and SET7); inhibits CARM1-mediated methylation of different substrates (PABP1, CA150, SmB, and H3) up to single-digit micromolar level, significantly and dose-dependently reduces the prostate-specific antigen (PSA) promoter activity in human prostate cancer LNCaP cells, does not affect cell viability.

References:

[1]. Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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