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RET-IN-1(LOXO-292)

  Cat. No.:  DC24201   Featured
Chemical Structure
2222755-14-6
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More than 5000 active chemicals with high quality for research!
Field of application
RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2222755-14-6
SMILES: N#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OC[C@H]7CNCCO7)=CN2N=C1
Formula: C29H31N9O3
M.Wt: 553.255
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Description: RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively [1].
Target: IC50: 1 nM (RETWT), 7 nM (RETV804M), 101 nM (RETG810R)
References: [1]. Steven W A, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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