GSK3145095|RIPK1 inhibitor|CAS 1622849-43-7

Cas No.:	1622849-43-7
Chemical Name:	(S)-5-benzyl-N-(7,9-difluoro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-4H-1,2,4-triazole-3-carboxamide
Synonyms:	GSK3145095，GSK-3145095，GSK 3145095
SMILES:	FC1=CC(F)=CC2=C1NC([C@@H](NC(C3=NNC(CC4=CC=CC=C4)=N3)=O)CC2)=O
Formula:	C₂₀H₁₇F₂N₅O₂
M.Wt:	397.38
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].
In Vitro:	GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC50 = 1.6 nM), cell death as measured by LDH release (IC50 = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC50 = 0.4 nM) [1].

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