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LXS-196

  Cat. No.:  DC26012   Featured
Chemical Structure
1874276-76-2
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Field of application
LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1874276-76-2
Chemical Name: LXS196
Synonyms: LXS196
SMILES: NC1=C(C(NC2=C(N3CCC(C)(N)CC3)C=CC=N2)=O)N=C(C4=NC=CC=C4C(F)(F)F)C=N1
Purity: >98%
Description: LXS196 is a potent and orally active protein kinase C (PKC) inhibitor under Phase I clinical trials for the treatment of uveal melanoma.
In Vitro: Upon oral administration, protein kinase C inhibitor LXS196 binds to and inhibits PKC, which prevents the activation of PKC-mediated signaling pathways. This may lead to the induction of cell cycle arrest and apoptosis in susceptible tumor cells. PKC, a serine/threonine protein kinase overexpressed in certain types of cancer cells, is involved in tumor cell differentiation, proliferation, invasion and survival[1].
References: [1]. Protein Kinase C Inhibitor LXS196
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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