FMF-04-159-2|CAS 2364489-81-4|DC Chemicals

Cas No.:	2364489-81-4
Chemical Name:	N-[1-[3-[[(E)-4-(Dimethylamino)but-2-enoyl]amino]phenyl]sulfonylpiperidin-4-yl]-4-[(2,4,6-trichlorobenzoyl)amino]-1H-pyrazole-5-carboxamide
Synonyms:	(E)-N-(1-((3-(4-(Dimethylamino)but-2-enamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide;N-[1-[3-[[(E)-4-(Dimethylamino)but-2-enoyl]amino]phenyl]sulfonylpiperidin-4-yl]-4-[(2,4,6-trichlorob;FMF-04-159-2
SMILES:	ClC1C([H])=C(C([H])=C(C=1C(N([H])C1C([H])=NN([H])C=1C(N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(C1=C([H])C([H])=C([H])C(=C1[H])N([H])C(/C(/[H])=C(\[H])/C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=O)(=O)=O)=O)=O)Cl)Cl
Formula:	C₂₈H₃₀Cl₃N₇O₅S
M.Wt:	683.0057
Purity:	>98%

Description:

FMF-04-159-2 is a potent, selective, covalent CDK14 inhibitor (IC50=86 nM) with pan-TAIRE family specificity (CDKs 14-18); potently inhibited the TAIRE kinases CDK14, CDK16, CDK17, and CDK18; CDK14 was potently engaged by FMF-04-159-2 (IC50=39.6 nM), and this engagement was sustained after a 2-h, compound washout (IC50=56.3 nM), indicates irreversible binding; FMF-04-159-2 is a valuable tool for study of CDK14 kinase function.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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