Cas No.: | 80714-61-0 |
Synonyms: | L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline |
SMILES: | O=C(O)[C@H]1N(C(CNC([C@H]2N(C([C@H](CC3=CC=CC=C3)NC([C@H](CC4=CNC=N4)NC([C@H](CCC(O)=O)NC([C@H](CCSC)N)=O)=O)=O)=O)CCC2)=O)=O)CCC1 |
Formula: | C37H51N9O10S |
M.Wt: | 813.9 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | Semax is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) (4-10) that has neuroprotective, analgesic, and anxiolytic properties.In vivo, semax (0.3 mg/kg) reduces cortical nitric oxide (NO) production and the number of neurological disturbances, such as seizures, falling, and twisting, in a rat model of global ischemia.It decreases acetic acid-induced writhing and nociception in a hind paw compression test in mice when administered at doses ranging from 0.015 to 0.5 mg/kg.Semax also increases time spent in the open arms in the elevated plus maze, indicating anxiolytic activity, in a rat model of maternal deprivation-induced anxiety. |