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SLMP53-1

  Cat. No.:  DC26112   Featured
Chemical Structure
1643469-17-3
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More than 5000 active chemicals with high quality for research!
Field of application
SLMP53-1 is a novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1643469-17-3
Chemical Name: (3S,9bR)-3-((1H-indol-3-yl)methyl)-9b-methyl-2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one
SMILES: [C@H0](C)12OC[C@H](CC3C4=C(NC=3)C=CC=C4)N1C(=O)C1=C2C=CC=C1
Formula: C20H18N2O2
M.Wt: 318.376
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells; enhances p53 transcriptional activity and restores wt-like DNA binding ability to mut p53R280K; inhibits the growth of wt/mut p53-expressing tumors in xenograft mice models, without apparent toxicity.
References: References 1. Soares J, et al. Oncotarget. 2016 Jan 26;7(4):4326-43. View Related Products by Target MDM2-p53
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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