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Thioquinapiperifil dihydrochloride

  Cat. No.:  DC44580   Featured
Chemical Structure
204077-66-7
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More than 5000 active chemicals with high quality for research!
Field of application
Thioquinapiperifil dihydrochloride (KF31327), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 204077-66-7
Chemical Name: Thioquinapiperifil Dihydrochloride
Synonyms: Thioquinapiperifil Dihydrochloride;KF-31327;Thioquinapiperifil D;3-ethyl-8-[[2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]methylamino]-1H-imidazo[4,5-g]quinazoline-2-thione;dihydrochloride;3-Ethyl-8-[2-[4-(hydroxymethyl)piperidin-1-yl]benzylamino]-2,3-dihydro-1H-imidazo[4,5-g]quinazoline-2-thione dihydrochloride;204077-66-7;SCHEMBL1961932;UNII-QJ87H5L241;CS-0159094;HY-119611A;kf31327;Thioquinapiperifil dihydrochloride;3-Ethyl-8-(2-(4-hydroxymethylpiperidino)benzylamino)-2,3-dihydro-1H-imidazo(4,5-g)quinazoline-2-thione dihydrochloride;YWGNFHIWAHNADT-UHFFFAOYSA-N;Q27287290;E77676;KF 31327;2H-Imidazo(4,5-g)quinazoline-2-thione, 3-ethyl-1,3-dihydro-8-(((2-(4-(hydroxymethyl)-1-piperidinyl)phenyl)methyl)amino)-, dihydrochloride;DB-218054;QJ87H5L241;AS-82728;THIOQUINAPIPERIFIL (DIHYDROCHLORIDE);2H-Imidazo(4,5-g)quinazoline-2-thione, 3-ethyl-1,3-dihydro-8-(((2-(4-(hydroxymethyl)-1-piperidinyl)phenyl)methyl)amino)-, hydrochloride (1:2)
SMILES: CCN1C2=C(C=C3C(=C2)N=CN=C3NCC4=CC=CC=C4N5CCC(CC5)CO)NC1=S.Cl.Cl
Formula: C24H28N6Os.2[HCl]
M.Wt: 521.5056
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_28286_DC44580_204077-66-7
COA
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Cat. No. Product name Field of application
DC73792 NSC74429 NSC74429 is a CNS-active, small molecule PHLPP inhibitor with IC50 of <5 uM, shows neuroprotective activity in primary rat cortical neurons in STS assay.
DC73789 K306 K306 is a small molecule agonist that specifically targets SH2-containing 5' inositol phosphatase 1 (SHIP1), an enzyme involved in regulating cellular signaling pathways. SHIP1 is a lipid phosphatase that hydrolyzes the 5' phosphate of phosphatidylinositol-3,4,5-trisphosphate (PIP3), converting it to phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2). This activity modulates the PI3K (phosphoinositide 3-kinase) signaling pathway, which is critical for cell survival, proliferation, and immune responses.
DC73788 K161 K161 is a potent, pan-SHIP1/2 inhibitor with IC50 of 1.5- 6 uM and 6.5-13 uM, respectively.
DC73764 CRD733 CRD733 (ASP4901) is a potent, selective cGMP-specific PDE9 (phosphodiesterase 9) inhibitor.
DC73763 CC-11050 Dovramilast (CC-11050) is a potent and orally active phosphodiesterase 4 (PDE4) inhibitor, CC-11050 is a promising candidate for host directed therapy of patients with pulmonary TB.
DC73761 NAMPT activator (NAT) NAMPT activator (NAT) is a potent, small molecule activator of nicotinamide phosphoribosyltransferase (NAMPT) with ITC KD of 500 nM.
DC73757 NCATS-SM7270 NCATS-SM7270 is a highly specific small molecule inhibitor of NADPH oxidase 2 (NOX2), exhibiting an IC50 value of 2.1 µM in polymorphonuclear leukocytes (PMN). It effectively inhibits NOX2 activity in both primary human and mouse granulocytes, demonstrating its targeted and potent mechanism of action.
DC73746 BAY-9835 BAY-9835 is the first orally bioavailable ADAMTS7 inhibitor with IC50 of 6 nM, which is selective against a range of off-targets and metalloproteases except for ADAMTS12.
DC73744 ADAM9i ADAM9i is a specific small molecule inhibitor of ADAM9 protein with binding KD of 5.9 uM and enzyme IC50 of 5.2 uM, promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy.
DC73741 MZ-101 MZ-101 is a potent, selective inhibitor of glycogen synthase 1 (GYS1) with IC50 of 41 nM (human GYS1), with no inhibition against GYS2.
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