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HQ461

  Cat. No.:  DC60254   Featured
Chemical Structure
1226443-41-9
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More than 5000 active chemicals with high quality for research!
Field of application
HQ461 is a molecular glue degrader that facilitates the interaction between CDK12 and the DDB1-CUL4-RBX1 E3 ubiquitin ligase, resulting in the polyubiquitination and subsequent degradation of the CDK12-interacting protein Cyclin K (CCNK). This degradation impairs CDK12 function, leading to reduced phosphorylation of its substrates, downregulation of DNA damage response genes, and ultimately, cell death.
Cas No.: 1226443-41-9
Chemical Name: 2-[2-[(6-Methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide
Synonyms: VU0528787-1;2-(2-((6-methylpyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide;2-[2-[(6-Methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide
SMILES: S1C([H])=C(C([H])([H])C(N([H])C2=NC([H])=C(C([H])([H])[H])S2)=O)N=C1N([H])C1=C([H])C([H])=C([H])C(C([H])([H])[H])=N1
Formula: C15H15N5Os2
M.Wt: 345.4425
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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