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VNPP433-3β

Cat. No.: DC67337 Featured

Chemical Structure

1630820-51-7

For research use only. We do not sell to patients.

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Field of application

VNPP433-3β is a first-in-class molecular glue degrader that simultaneously targets androgen receptor (AR), its splice variants (AR-Vs), and Mnk1/2 kinases for proteasomal degradation. This multimodal agent demonstrates potent anti-proliferative activity in castration-resistant prostate cancer (CRPC) models, with GI50 values of 0.2–0.31 μM in LNCaP, C4-2B, and CWR22Rv1 cells. Its robust in vivo efficacy, evidenced by tumor growth inhibition in CWR22Rv1 xenografts, is supported by favorable pharmacokinetics in CD-1 mice.

Chemicals Properties Biological activity Related products COA MSDS Datasheet

Cas No.:	1630820-51-7
Chemical Name:	VNPP433-3β
Synonyms:	Galeterone 3β-imidazole
SMILES:	C[C@@]12[C@](CC=C2N3C4=CC=CC=C4N=C3)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@@H](N7C=CN=C7)CC6)=CC5)C)([H])CC1
Formula:	C₂₉H₃₄N₄
M.Wt:	438.61
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC68076	BG-BRD4-P07
DC68075	BRU-SHP2-P06
DC68074	LLY-ESR1-P05
DC68073	AST-AR-P04
DC68072	NOV-EP001
DC68071	JHU-MDM2-P03
DC68070	CAS-FAK-P02
DC68069	MDA-S24-P01
DC68068	TB-008
DC68067	ARV-863

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.