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IKZF3 degrader 1

Cat. No.: DC67375 Featured

Chemical Structure

For research use only. We do not sell to patients.

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Field of application

IKZF3 degrader 1 (compound 19a) is a potent molecular glue that induces targeted IKZF3 degradation (EC50 = 12 nM) by facilitating its recruitment to the cereblon (CRBN) E3 ubiquitin ligase complex. This enforced protein-protein interaction triggers subsequent ubiquitination and proteasomal elimination of IKZF3.

Chemicals Properties Biological activity Related products COA MSDS Datasheet

Cas No.:
Chemical Name:	IKZF3 degrader 1
SMILES:	O=C([C@@]1(C2=CC=C(Br)C=C2)C(C3=CC=CC4=C3CN(C(CC5)C(NC5=O)=O)C4=O)=C1)OCC(Cl)(Cl)Cl
Formula:	C₂₅H₁₈BrCl₃N₂O₅
M.Wt:	612.68
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC68076	BG-BRD4-P07
DC68075	BRU-SHP2-P06
DC68074	LLY-ESR1-P05
DC68073	AST-AR-P04
DC68072	NOV-EP001
DC68071	JHU-MDM2-P03
DC68070	CAS-FAK-P02
DC68069	MDA-S24-P01
DC68068	TB-008
DC68067	ARV-863

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.