DK419|DK-419;DK 419

Cas No.:	2102672-22-8
Chemical Name:	6-chloro-2-(trifluoromethyl)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamide
Synonyms:	DK-419;DK 419
SMILES:	C(C(F)(F)F)1=NC2=C(C(NC3=CC=C(C(F)(F)F)C=C3)=O)C=C(Cl)C=C2N1
Formula:	C₁₆H₈ClF₆N₃O
M.Wt:	407.7
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

DK419 (DK-419) a potent, orally acitve inhibitor of Wnt/β-catenin signaling with IC50 of 0.19 uM in Wnt3A-stimulated TOPFlash assays; reduces levels of Wnt/β-catenin target gene proteins (Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin) in CRC tumor cell models, increases oxygen consumption rate and induces pAMPK in cell culture; potently inhibit the proliferation of CRC tumor cell lines (SW948 cell IC50=0.07 uM); displays inhibition of tumor growth in mouse CRC240 PDX tumor model.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
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DC37901	PD-173212	PD-173212 is a small molecule N-type calcium channel blocker.
DC37333	N,N-Diethyl-p-toluamide	N,N-Diethyl-p-toluamide is a mosquito repellent.
DC37321	AI3-15902	AI3-15902 is a biochemical.
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DC37252	Ampyrone	Ampyrone is a metabolite of AMINOPYRINE with analgesic and anti-inflammatory properties. It is used as a reagent for biochemical reactions producing peroxides or phenols. Ampyrone stimulates LIVER MICROSOMES and is also used to measure extracellular water.
DC37245	Piperonyl butoxide	Piperonyl butoxide (PBO) is an organic compound used as a component of pesticide formulations. It is a waxy white solid. It is a synergist. That is, despite having no pesticidal activity of its own, it enhances the potency of certain pesticides such as carbamates, pyrethrins, pyrethroids, and rotenone.[1] It is a semisynthetic derivative of safrole.
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