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DOTATATE acetate

  Cat. No.:  DC40062   Featured
Chemical Structure
177943-89-4
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More than 5000 active chemicals with high quality for research!
Field of application
DOTATATE acetate, a DOTA-conjugated peptide, and can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide therapy (PRRT).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 177943-89-4
Chemical Name: DOTA-TATE acetate
Synonyms: {D-Phe}-CY-{D-Trp}-KTCT (Disulfide bridge:Cys2-Cys7)
SMILES: [{D-Phe}-CY-{D-Trp}-KTCT (Disulfide bridge:Cys2-Cys7) (acetate salt)]
Formula: C67H94N14O21S2
M.Wt: 1495.69
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
Description: DOTATATE acetate, a DOTA-conjugated peptide, and can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide therapy (PRRT)[1][2][3][4].
In Vivo: 177Lu-DOTATATE shows excellent antitumor effects in rats[1].
References: [1]. Jong M, et, al. Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs. J Nucl Med. 2005 Jan;46 Suppl 1:13S-7S. [2]. Gains JE, et, al. 68Ga-DOTATATE and 123I-mIBG as imaging biomarkers of disease localisation in metastatic neuroblastoma: implications for molecular radiotherapy. Nucl Med Commun. 2020 Aug 10. [3]. Breeman WAP, et, al. Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities. Eur J Nucl Med Mol Imaging. 2003 Jun;30(6):917-20. [4]. Reubi JC, et, al. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med. 2000 Mar;27(3):273-82.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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