Cas No.: | 60940-34-3 |
Chemical Name: | 2-Phenylbenzo[d][1,2]selenazol-3(2H)-one |
Synonyms: | 2-Phenylbenzo[d][1,2]selenazol-3(2H)-one;2-Phenyl-1,2-benzisoselenazol-3(2H)-one;Ebselen;1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-;2-Phenyl-1,2-benzose;2-phenyl-1,2-benzoselenazol-3-one;CCG-39161;Ebselene;Ebseleno;Ebselenum;Harmokisane;PZ-51;SPI1005;SPI-1005;2-Phenyl-1,2-benzoisoselenazol-3(2H)-one;2-Phenyl-benzo[d]isoselenazol-3-one |
SMILES: | O=C1N(C2=CC=CC=C2)[Se]C3=C1C=CC=C3 |
Formula: | C13H9NOse |
M.Wt: | 274.17666 |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.Target:Ebselen is an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. [1] Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase). Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. [2] |