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FK-888

  Cat. No.:  DC33273   Featured
Chemical Structure
138449-07-7
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More than 5000 active chemicals with high quality for research!
Field of application
FK-888 is a selective, high affinity tachykinin NK1 receptor antagonist (Ki = 0.69 nM) that displays 320-fold selectivity for human over rat NK1 receptors. FK-888 inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 138449-07-7
Chemical Name: FK 888
Synonyms: L-Alaninamide,(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-;(2S,4R)-N-[(2S)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-4-hydroxy-1-(1-methylindole-3-carbonyl)pyrrolidine-2-carboxamide;FK 888;FK-888;L-Alaninamide,(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-napht...;(4R)-4-Hydroxy-1-[(1-Methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-Methyl-3-(2-naphthalenyl)-N-(phenylMethyl)-L-alaninaMide;HMS3269A13;BRD-K83508485-001-01-9;FK888;CS-0025377;L-Alaninamide, trans-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-;(2S)-N-benzyl-2-{[(2S,4R)-4-hydroxy-1-(1-methyl-1H-indole-3-carbonyl)pyrrolidin-2-yl]formamido}-N-methyl-3-(naphthalen-2-yl)propanamide;(2S,4R)-4-hydroxy-1-(1-methylindole-3-carbonyl)-N-[(2S)-1-(methyl-(phenylmethyl)amino)-3-naphthalen-2-yl-1-oxopropan-2-yl]pyrrolidine-2-carboxamide;HY-105215;L-Alaninamide, trans-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-;CHEBI:93463;L-Alaninamide, (4R)-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-;L-Alaninamide, (4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-;Q27077302;DTXSID70160680;DZQ7B7BPD4;AKOS024457076;SCHEMBL8079679;NCGC00159560-01;PDSP2_000648;CHEMBL1416993;HMS3677K12;GTPL2114;HMS3413K12;138449-07-7;BRD-K83508485-001-03-5;N(2)-(4-Hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl)-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide;BRD-K83508485-001-02-7;DA-73376;(2S,4R)-4-hydroxy-1-(1-methylindole-3-carbonyl)-N-((2S)-1-(methyl-(phenylmethyl)amino)-3-naphthalen-2-yl-1-oxopropan-2-yl)pyrrolidine-2-carboxamide;DTXCID0083171;(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide
SMILES: OC1CN(C(C2C3C(=CC=CC=3)N(C)C=2)=O)C(C(NC(C(N(C)CC2C=CC=CC=2)=O)CC2C=CC3C(=CC=CC=3)C=2)=O)C1
Formula: C36H36N4O4
M.Wt: 588.69544
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_15584_DC33273_138449-07-7
COA
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