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Fostemsavir(BMS-663068)

  Cat. No.:  DC8163   Featured
Chemical Structure
864953-29-7
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More than 5000 active chemicals with high quality for research!
Field of application
HIV-1 attachment inhibitor,a prodrug of the small-molecule inhibitor BMS-626529
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 864953-29-7
Chemical Name: BMS 663068
Synonyms: BMS 663068;[3-[2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl]-4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)pyrrolo[2,3-c]pyridin-1-yl]methyl dihydrogen phosphate;BMS-663068;FOSTEMSAVIR
SMILES: O=C(N1CCN(C(C2=CC=CC=C2)=O)CC1)C(C3=CN(COP(O)(O)=O)C4=C3C(OC)=CN=C4N5N=C(C)N=C5)=O
Formula: C25H26N7O8P
M.Wt: 583.48984
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Fostemsavir (also known Fostemsavir (BMS-663068) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir (BMS-663068) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.
In Vivo: Fostemsavir (BMS-663068) has good antiviral activity in subjects infected with virus shown to be susceptible (IC50, <100 nM) to the agent[1].
References: [1]. Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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