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GW-506033X(PKR Inhibitor C16)

  Cat. No.:  DC33146   Featured
Chemical Structure
608512-97-6
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More than 5000 active chemicals with high quality for research!
Field of application
C16, also known as GW-506033X or PKR Inhibitor. C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. GW-506033X protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. PKR inhibitor C16 binds efficiently with human microtubule affinity-regulating kinase 4.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 608512-97-6
Chemical Name: 6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
Synonyms: GW-506033X; GW 506033X; GW506033X; C16, PKR Inhibitor.
SMILES: O=C1/C(C2=C(SC=N3)C3=CC=C2N1)=C\C4=CN=CN4
Formula: C13H8N4Os
M.Wt: 268.294
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: GW-506033X(PKR Inhibitor C16) is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures[1].
References: [1]. Tronel C, et al. The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan;64:73-83.
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