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GW284543 (UNC10225170)

  Cat. No.:  DC26164   Featured
Chemical Structure
790186-68-4
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More than 5000 active chemicals with high quality for research!
Field of application
GW284543 (UNC10225170) is a selective MEK5 inhibitor. GW284543 (UNC10225170) reduces pERK5, and decreases endogenous MYC protein.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 790186-68-4
Synonyms: GW284543,UNC10225170,GW-284543,UNC-10225170,GW 284543,UNC 10225170
SMILES: COC1=CC2=C(NC3=CC(OC4=CC=CC=C4)=CC=C3)C=CN=C2C=C1OC
Formula: C23H20N2O3
M.Wt: 372.42
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Description: GW284543 (UNC10225170) is a selective MEK5 inhibitor[1].
Target: MEK5
In Vitro: GW284543 (UNC10225170) treatment dose dependently inhibits MEK5, as determined by reductions in pERK5, and decreased endogenous MYC protein[1].
References: [1]. Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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