HLCL-61|CAS 1158279-20-9|DC Chemicals

Cas No.:	1158279-20-9
Chemical Name:	HLCL-61 HCl
Synonyms:	HLCL-61 (hydrochloride);HLCL61 hydrochloride;HLCL-61 hydrochloride
SMILES:	[H]Cl.COC1=CC=CC=C1CNCC2=CC3=C(C=C2)N(CC)C4=C3C=CC=C4
Formula:	C₂₃H₂₅ClN₂O
M.Wt:	380.916
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

HLCL-61 hydrochloride is a first-in-class small-molecule inhibitor of PRMT5. Target: PRMT5in vitro: HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h. Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also resulted in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h.[1]

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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