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ICA 110381 (Compound 16)

  Cat. No.:  DC26167   Featured
Chemical Structure
325457-99-6
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Field of application
ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 325457-99-6
Synonyms: ICA110381,ICA-110381,ICA 110381,CAS 325457-99-6
SMILES: O=C(NC1=CC=C(Cl)N=C1)C2=CC=C(Cl)C=C2
Formula: C12H8Cl2N2O
M.Wt: 267.11
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Description: ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].
Target: EC50: 0.38 μM (KCNQ2/Q3 potassium channel)[1] IC50: 15 μM (KCNQ1)[1]
References: [1]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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