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(R)-IMPP

  Cat. No.:  DC10521   Featured
Chemical Structure
2133832-83-2
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More than 5000 active chemicals with high quality for research!
Field of application
(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 µM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2133832-83-2
Chemical Name: R-IMPP
Synonyms: R-IMPP;Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl-
SMILES: C1(CCC(N(C2C3=C(C=CC=C3)C=CN=2)[C@@H]2CCCNC2)=O)=CC=C(OC)C=C1
Formula: C24H27N3O2
M.Wt: 389.5
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: R-IMPP is an inhibitor of PCSK9 secretion.
In Vitro: R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP does not decrease PCSK9 transcription or increase PCSK9 degradation, but causes transcript-dependent inhibition of PCSK9 translation. R-IMPP is able to selectively bind to human, but not E. coli, ribosomes[1].
References: [1]. Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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