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JH295

  Cat. No.:  DC40234  
Chemical Structure
1311143-71-1
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More than 5000 active chemicals with high quality for research!
Field of application
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1311143-71-1
Chemical Name: JH295
SMILES: C#CC(NC1=CC2=C(NC(/C2=C\C3=C(C)N=C(CC)N3)=O)C=C1)=O
Formula: C18H16N4O2
M.Wt: 320.35
Sotrage: -20°C, stored under nitrogen*The compound is unstable in solutions, freshly prepared is recommended.
MSDS
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MSDS_23247_DC40234_1311143-71-1
COA
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Cat. No. Product name Field of application
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