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JT010

  Cat. No.:  DC33149   Featured
Chemical Structure
917562-33-5
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More than 5000 active chemicals with high quality for research!
Field of application
JT010 is a potent agonist of TRPA1 with an EC50 of 0.65 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 917562-33-5
Chemical Name: 2-Chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)-acetamide
Synonyms: JT010; JT-010; JT 010.
SMILES: O=C(N(C1=NC(C2=CC=C(OC)C=C2)=CS1)CCCOC)CCl
Formula: C16H19ClN2O3S
M.Wt: 354.849
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
Publication: [1]. Takaya J, et al. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23;137(50):15859-64.
Description: JT010 is a potent and TRPA1-selective channel activator via covalent modification of TRPA1 active site Cys621. JT010 opens the TRPA1 channel by covalently and site-selectively binding to Cys621 (EC50 = 0.65 nM). The results suggest that a single modification of Cys621 is sufficient to open the TRPA1 channel. The TRPA1-selective probe described herein might be useful for further mechanistic studies of TRPA1 activation.
Target: EC50: 0.65 nM (TRPA1)[1]
References: [1]. Takaya J, et al. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23;137(50):15859-64.
MSDS
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MSDS_15460_DC33149_917562-33-5
COA
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