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KAG-308

  Cat. No.:  DC40396  
Chemical Structure
1215192-68-9
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More than 5000 active chemicals with high quality for research!
Field of application
KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a Ki and an EC50 of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1215192-68-9
Chemical Name: KAG-308
SMILES: O[C@H](C1)[C@H](/C=C/[C@@H](O)[C@@H](C2=CC=CC(C)=C2)C)[C@](C/3(F)F)([H])[C@@]1([H])OC3=C/CCCC4=NN=NN4
Formula: C24H30F2N4O3
M.Wt: 460.52
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC42503 Taprenepag isopropyl Taprenepag isopropyl is a highly selective EP2 receptor agonist.
DC47374 Aligeron Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.
DC47373 CAY10580 CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM).
DC47183 Aganepag isopropyl Aganepag isopropyl (AGN-210961) is an EP2 agonist.
DC47172 15-Keto latanoprost 15-Keto latanoprost is a metabolite of Latanoprost, which is an ocular hypotensive agent.
DC47127 Pexopiprant Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),Ki ＜ 100nM. Pexopiprant can be used in studies of asthma.
DC47089 Treprostinil palmitil Treprostinil palmitil (TP) is the prodrug of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC50 values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure prodrug and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors.
DC46853 BGC-20-1531 free base BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKb of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache.
DC46564 Bimatoprost D5 Bimatoprost D5 (AGN 192024 D5) is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect.
DC45799 TCS 2510 TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases.
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