KL-2|KL2|SEC inhibitor|900308-51-2|DC Chemicals

Cas No.:	900308-51-2
Chemical Name:	N-(5-chloro-2-methylphenyl)-4-(4-fluorophenyl)-2,4-dioxobutanamide
Synonyms:	KL2,KL-2,KL 2
SMILES:	C1=CC(F)=CC=C1C(CC(C(=O)NC1=CC(Cl)=CC=C1C)=O)=O
Formula:	C₁₇H₁₃ClFNO₃
M.Wt:	333.06
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Liang K, et al. Cell. 2018 Oct 18;175(3):766-779.e17.

Description:

SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1].

MSDS

COA

LOT NO.	DOWNLOAD
2018-0101

2018-0101
2018-0101

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