KPT-185|cas 1333151-73-7|DC Chemicals|Price|Buy

Cas No.:	1333151-73-7
Chemical Name:	2-Propenoic acid, 3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 1-methylethyl ester, (2Z)-
Synonyms:	KPT185; KPT 185
SMILES:	O=C(OC(C)C)/C=CN1N=C(C2=CC(C(F)(F)F)=CC(OC)=C2)N=C1
Formula:	C₁₆H₁₆F₃N₃O₃
M.Wt:	355.31
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts. KPT-185 reduces CRM1 protein protein level and shows a significant nuclear accumulation of CRM1 cargo proteins. KPT-185 also inhibits proliferation and promotes apoptosis of pancreatic cancer cells without affecting human pancreatic ductal epithelial cells. For the detailed information of KPT-185, the solubility of KPT-185 in water, the solubility of KPT-185 in DMSO, the solubility of KPT-185 in PBS buffer, the animal experiment (test) of KPT-185, the cell expriment (test) of KPT-185, the in vivo, in vitro and clinical trial test of KPT-185, the EC50, IC50,and Affinity of KPT-185, Please contact DC Chemicals.

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