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LC-2

  Cat. No.:  DC42435   Featured
Chemical Structure
2502156-03-6
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Field of application
LC-2 is a potent and first-in-class degrader of endogenous KRAS G12C with DC50 values between 0.25 and 0.76 μM. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2502156-03-6
Chemical Name: LC-2
Synonyms: LC-2;LC 2;LC2
SMILES: O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCOCCCN4[C@@H](CCC4)COC5=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C7C(CN(CC7)C8=C9C(Cl)=CC=CC9=CC=C8)=N5)=O)=O
Formula: C59H71ClFN11O7S
M.Wt: 1132.78
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
Publication: [1]. De Vita E, et al. The Missing Link between (Un)druggable and Degradable KRAS. ACS Cent Sci. 2020;6(8):1281-1284. [2]. Bond MJ, et al. Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs. ACS Cent Sci. 2020;6(8):1367-1375.
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