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Longdaysin

  Cat. No.:  DC26161   Featured
Chemical Structure
1353867-91-0
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More than 5000 active chemicals with high quality for research!
Field of application
Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1353867-91-0
Synonyms: Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling.
SMILES: FC(F)(F)C1=CC=CC(CNC2=NC=NC3=C2N=CN3C(C)C)=C1
Formula: C16H16F3N6
M.Wt: 335.33
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Description: Longdaysin is a CK1α, CK1δ, and extracellular signal-regulated kinase 2 (ERK2) inhibitor with IC50s of  5.6 µM, 8.8 µM, and 52 µM, respectively[1][2].
Target: CKIα:5.6 μM (IC50) CKIδ:8.8 μM (IC50) ERK2:52 μM (IC50)
References: [1]. 1. Griffett K, et al. The mammalian clock and chronopharmacology. Bioorganic & Medicinal Chemistry Letters, 2013, 23(7):1929-1934.. [2]. Hirota T, et al. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol. 2010 Dec 14;8(12):e1000559.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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