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Idalopirdine Hydrochloride

  Cat. No.:  DC32766   Featured
Chemical Structure
467458-02-2
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More than 5000 active chemicals with high quality for research!
Field of application
Idalopirdine, also known as Lu AE58054 or Iladopirdine, is a potent and selective 5-HT6 receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia. It is in phase III clinical trials. Lu AE58054 displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a Ki of 0.83 nm. Lu AE58054 demonstrated >50-fold selectivity for more than 70 targets examined. Lu AE58054 is a selective antagonist of 5-HT(6)Rs with good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia. Lu AE58054 may be useful for the pharmacotherapy of cognitive dysfunction in disease states such as schizophrenia and Alzheimer's disease.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 467458-02-2
Chemical Name: Idalopirdine hydrochloride
Synonyms: HY-14338A;CS-1359;Lu AE58054 Hydrochloride;QC-10464;N-(2-(6-fluoro-1H-indol-3-yl)ethyl)-3-(2,2,3,3-tetrafluoropropoxy)benzylamine hydrochloride;2-(6-fluoro-1H-indol-3-yl)-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]ethanamine,hydrochloride;6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-1H-Indole-3-ethanamine hydrochloride;LuAE58054;2-(6-fluoro-1H-indol-3-yl)-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]ethanamine;hydrochloride;Idalopirdine Hydrochloride;Lu AE58054 (Hydrochloride);Lu AE 58054 Hydrochloride;Lu AE58054 HCl;545BT5182Y;Idalopirdine HCl;Idalopirdine hydrochloride (JAN);BCP14749;AK547815;AB0098104;A14356;D10747;Idalopirdine Hydrochloride;Lu AE
SMILES: Cl[H].FC1C([H])=C([H])C2=C(C=1[H])N([H])C([H])=C2C([H])([H])C([H])([H])N([H])C([H])([H])C1C([H])=C([H])C([H])=C(C=1[H])OC([H])([H])C(C([H])(F)F)(F)F
Formula: C20H20ClF5N2O
M.Wt: 434.8306
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_15078_DC32766_467458-02-2
COA
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