ML-239|ML239|CAS 1378872-36-6

Cas No.:	1378872-36-6
Chemical Name:	2-(2,4,6-trichlorophenoxy)-acetic acid, (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide
Synonyms:	CID-49843203,CID 49843203,CID49843203,ML-239,ML 239,ML239,1378872-36-6
SMILES:	O=C(COC1=C(Cl)C=C(Cl)C=C1Cl)N/N=C/C2=CC=CN2
Formula:	C₁₃H₁₀Cl₃N₃O₂
M.Wt:	346.6
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.

In Vitro:

ML239 (Compound 7j) is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ∼24-fold selectivity against the control cell line[1]. ML239 inhibits breast cancer stem-like cells, most likely through activation of fatty acid desaturase 2 (FADS2). ML239 is cytotoxic to NCIH661 cells, and FADS2 knockdown reduces ML239 cytotoxicity, and furthermore, FADS2 inhibitor SC-26196 also reduces ML239 cytotoxicity in cancer cell lines (CCLs)[2].

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