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MitoBloCK-11

  Cat. No.:  DC12626   Featured
Chemical Structure
413606-16-3
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More than 5000 active chemicals with high quality for research!
Field of application
MitoBloCK-11 (MB-11) is a s mall molecule inhibitor of mitochondrial protein import possibly acts through transport protein Seo1, but not Tom70 or Tom20; inhibits precursor proteins that contain hydrophobic segments, confers growth in media lacking uracil in a specific manner and affects zebrafish development.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 413606-16-3
Chemical Name: 2-((4-bromonaphthalen-1-yl)oxy)-N'-((5-nitrothiophen-2-yl)methylene)acetohydrazide
Synonyms: MB-11
SMILES: C(N/N=C/C1SC([N+]([O-])=O)=CC=1)(=O)COC1=C2C(C=CC=C2)=C(Br)C=C1
Formula: C17H12BrN3O4S
M.Wt: 434.264
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Conti, M. (2018). Small Molecule Probes of Mitochondrial Translocases Elucidate PINK1 Trafficking in PINK1/Parkin Regulated Mitophagy. UCLA. 2. Miyata N, et al. J Biol Chem. 2017 Mar 31;292(13):5429-5442.
Description: MitoBloCK-11 (MB-11) is a s mall molecule inhibitor of mitochondrial protein import possibly acts through transport protein Seo1, but not Tom70 or Tom20; inhibits precursor proteins that contain hydrophobic segments, confers growth in media lacking uracil in a specific manner and affects zebrafish development.
References: References 1. Conti, M. (2018). Small Molecule Probes of Mitochondrial Translocases Elucidate PINK1 Trafficking in PINK1/Parkin Regulated Mitophagy. UCLA. 2. Miyata N, et al. J Biol Chem. 2017 Mar 31;292(13):5429-5442. View Related Products by Target Other Targets
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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