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NEK6 inhibitor 8

  Cat. No.:  DC12465   Featured
Chemical Structure
591239-68-8
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Field of application
NEK6 inhibitor 8(ZINC05007751) is a novel inhibitor of the NIMA-related kinase NEK6 with IC50 of 3.4 uM, compound 8 is very selective against NEK1 and NEK6, while no signifcant activity was observed against NEK2, NEK7, and NEK9.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 591239-68-8
Chemical Name: (5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile
Synonyms: ZINC05007751
SMILES: C(O)1=NC(=O)/C(=C\C2=CC=C(C3=CC=CC=C3)O2)/C(C)=C1C#N
Formula: C18H12N2O3
M.Wt: 304.305
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: NEK6 inibitor 8 (ZINC05007751) is a novel inhibitor of the NIMA-related kinase NEK6 with IC50 of 3.4 uM, compound 8 is very selective against NEK1 and NEK6, while no signifcant activity was observed against NEK2, NEK7, and NEK9; dispalys antiproliferative activity against a panel of human cancer cell lines (IC50 <100 uM).
References: References 1. De Donato M, et al. Sci Rep. 2018 Oct 30;8(1):16047. View Related Products by Target Other Targets
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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