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NSC228155

  Cat. No.:  DC12657   Featured
Chemical Structure
113104-25-9
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More than 5000 active chemicals with high quality for research!
Field of application
NSC228155 is an activator of EGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 113104-25-9
Synonyms: NSC228155,NSC-228155,NSC 228155
SMILES: O=[N+](C1=CC=C(SC2=CC=CC=[N+]2[O-])C3=NON=C31)[O-]
Formula: C11H6N4O4S
M.Wt: 290.25
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: NSC 228155 is a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM. NSC 228155 is not selective against CREB-mediated gene transcription in living HEK 293T cells[1].
Target: IC50: 0.36 μM (KIX-KID)[1]
In Vitro: NSC 228155 (Compound 1) inhibits CREB- and VP16-CREB-mediated gene transcription in living HEK 293T cells with an IC50 of 2.09 and 6.14 μM, respectively[1].
References: [1]. Xie F, et al. Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5371-5.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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