Nolatrexed (AG-337)From supplier DC Chemicals

Cas No.:	152946-68-4
Chemical Name:	Nolatrexed HCl
Synonyms:	AG337; AG 337; AG-337; Nolatrexed HCl; Nolatrexed dihydrochloride; brand name: Thymitaq.
SMILES:	CC1=C(SC2=CC=NC=C2)C(C3=O)=C(N=C(N)N3)C=C1
Formula:	C₁₄H₁₄Cl₂N₄Os
M.Wt:	357.25
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells[2].

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