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PRLX93936

  Cat. No.:  DC31276   Featured
Chemical Structure
903499-49-0
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More than 5000 active chemicals with high quality for research!
Field of application
PRLX 93936 is a structural analogue of erastin with potential antineoplastic activity. Erastin analogue PRLX 93936 appears to inhibit mitochondrial outer membrane protein VDACs (voltage-dependent anion channels) 2 and 3, resulting in an oxidative, non-apoptotic cell death. Erastin analogue PRLX 93936 exhibits greater lethality in cell lines harboring mutations in the GTPase protein oncogenes HRAS and KRAS or the serine-threonine protein kinase oncogene BRAF than in non-tumorigenic cell lines. VDACs 2 and 3 are up-regulated in a wide variety of tumor cell lines.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 903499-49-0
Chemical Name: 3-(2-ethoxyphenyl)-2-(1-piperazinylmethyl)-4(3H)-quinazolinone
SMILES: N1C2=C(C=CC=C2)C(=O)N(C2=CC=CC=C2OCC)C=1CN1CCNCC1
Formula: C21H24N4O2
M.Wt: 364.440864562988
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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