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Home > Inhibitors & Agonists > Epigenetics > HDAC

PTACH (NCH-51)

  Cat. No.:  DC8654   Featured
Chemical Structure
848354-66-5
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More than 5000 active chemicals with high quality for research!
Field of application
PTACH (NCH-51) is a SAHA-based novel inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 848354-66-5
Synonyms: NCH-51
SMILES: C(SCCCCCCC(=O)NC1=NC(C2=CC=CC=C2)=CS1)(=O)C(C)C
Formula: C20H26N2O2S2
M.Wt: 390.56
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: PTACH (NCH-51) is a SAHA-based novel inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM.
Target: IC50 value: 1-10 μM (EC50) Target: HDAC
In Vitro: In cancer cell growth inhibition assay, PTACH shows strong activity. PTACH inhibits various cancer cells with EC50 of 2.3, 9.1, 3.0, 2.6, 1.1, 4.5, 2.4, 5.0, and 4.5 μM for MDA-MB-231 breast cancer, SNB-78 central nervous system, HCT116 colon cancer, NCI-H226 lung cancer, LOX-IMVI melanoma, SK-OV-3 ovarian cancer, RXF-631L renal cancer, St-4 stomach cancer, and DU-145 prostate cancer.
References: [1]. Suzuki T, et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48(4):1019-1032.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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