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Pseudouridine

  Cat. No.:  DC32226   Featured
Chemical Structure
1445-07-4
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Field of application
Pseudouridine (abbreviated by the Greek letter psi- Ψ) is an isomer of the nucleoside uridine in which the uracil is attached via a carbon-carbon instead of a nitrogen-carbon glycosidic bond. It is the most prevalent of the over one hundred different modified nucleosides found in RNA. Ψ is found in all species and in many classes of RNA. Ψ is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1445-07-4
Chemical Name: 5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Synonyms: 5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;BETA-PSEUDOURIDINE;2,4(1H,3H)-Pyrimidinedione,5-b-D-ribofuranosyl-;Pseudouridine;β-Pseudouridine
SMILES: OC1C(O)C(CO)OC1C1=CNC(=O)NC1=O
Formula: C9H12N2O6
M.Wt: 244.201382637024
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Pseudouridine, the most abundant modified nucleoside in non-coding RNAs, enhances the function of transfer RNA and ribosomal RNA by stabilizing RNA structure.
Target: Human Endogenous Metabolite
References: [1]. Carlile TM, et al. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Nature. 2014 Nov 6;515(7525):143-6.
MSDS
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MSDS_14538_DC32226_1445-07-4
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