RTS-V5|Dual HDAC-proteasome inhibitor RTS-V5

Cas No.:	2285346-31-6
Chemical Name:	Chembl4167623
Synonyms:	RTS-V5;N1-((S)-1-(((S)-1-(Benzylamino)-1-oxopropan-2-yl)amino)-4-(neopentylamino)-1,4-dioxobutan-2-yl)-N4-hydroxyterephthalamide;FGY;N-(2,2-dimethylpropyl)-N~2~-[4-(hydroxycarbamoyl)benzene-1-carbonyl]-L-asparaginyl-N-benzyl-L-alaninamide;BDBM50450706;Chembl4167623
SMILES:	O=C(C[C@@H](C(N[C@H](C(NCC1C=CC=CC=1)=O)C)=O)NC(C1C=CC(C(NO)=O)=CC=1)=O)NCC(C)(C)C
Formula:	C₂₇H₃₅N₅O₆
M.Wt:	525.596706628799
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5) is the first-in-class, dual HDAC-proteasome inhibitor with IC50 of 0.27 uM (HDAC6), inhibits HDAC8 (IC50=0.53 uM), and low activity against HDAC/1/2/3; demonstrates cytotoxicity against leukemia and multiple myeloma cell lines as well as therapy-refractory primary patient-derived leukemia cells.

Cat. No.	Product name	Field of application
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