Rbin-1|Ribozinoindole-1

Cas No.:	328023-11-6
Chemical Name:	Rbin 1,Ribozinoindole 1,Rbin1,Ribozinoindole-1,Rbin-1,Ribozinoindole1
Synonyms:	Rbin 1,Ribozinoindole 1,Rbin1,Ribozinoindole-1,Rbin-1,Ribozinoindole1
SMILES:	CC(C)(CO)[C@@H](O)C(NCCC(CC1=CC=CC=C1)=O)=O
Formula:	C₁₆H₂₃NO₄
M.Wt:	293.36
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Rbin-1 is a potent, reversible, and specific chemical inhibitor of eukaryotic ribosome biogenesis. Rbin-1 inhibits the ATPase with GI50 of 136±7 nM.

In Vitro:

Rbin-1 is a potent and reversible triazinoindole-based inhibitors of eukaryotic ribosome biogenesis. Rbin-1 inhibits recombinant full-length Mdn1’s ATPase activity. Two of the active analogs (Rbin-1 and Rbin-2) inhibit the ATPase activity by 40% at 1 uM. In particular, an analog (Rbin-2) with a bromine substituent at postion-7 is 10-fold more active than Rbin-1 (GI50=14±1 nM (Rbin-2); 136±7 nM (Rbin-1), n=4, mean±SD)[1].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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