Remodelin (hydrobromide)|Purchase|DC CHEM

Cas No.:	1622921-15-6
Chemical Name:	Remodelin HBr
SMILES:	C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1.Br
Formula:	C₁₅H₁₅BrN₄S
M.Wt:	363.28
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Remodelin HBr salt is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.Remodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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