(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2|CAS 2409538-69-6|DC Chemicals

Cas No.:	2409538-69-6
Chemical Name:	(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2
SMILES:	NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O
Formula:	C₃₁H₄₇N₅O₇S
M.Wt:	633.80
Purity:	>98%
Sotrage:	Please store the product under the recommended conditions in the Certificate of Analysis.
Publication:	[1]. Marı A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312.

Description:

(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 can be used in PROTAC BRD4 Degrader-5 and PROTAC BRD4 Degrader-5-CO-PEG3-N3

Cat. No.	Product name	Field of application
DC39625	(S,R,S)-AHPC-PEG4-NH2 hydrochloride	VH 032 Linker 2 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1.
DC50079	Thalidomide-O-amido-C5-NH2	Thalidomide-O-amido-C5-NH2 is a novel PROTAC building block.
DC50078	(S,R,S)-AHPC-Me-C8-NH2	(S,R,S)-AHPC-Me-C8-NH2 is a novel PROTAC building block.
DC50077	(S,R,S)-AHPC-Me-C4-NH2	(S,R,S)-AHPC-Me-C4-NH2 is a novel PROTACA building block.
DC50076	(S,R,S)-AHPC-Me-C3-NH2	(S,R,S)-AHPC-Me-C3-NH2 is a novel PROTAC building block.
DC50075	(S,R,S)-AHPC-Me-C2-NH2	(S,R,S)-AHPC-Me-C2-NH2 is a novel PROTAC building block.
DC50074	(S,R,S)-AHPC-Me-C1-NH2	(S,R,S)-AHPC-Me-C1-NH2 is a novel PROTAC Building block.
DC50070	(S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base)	(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
DC50069	(S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7)	(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
DC50068	(S,R,S)-AHPC-Me-C10-NH2	(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432