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Dilmapimod (SB-681323)

  Cat. No.:  DC31346   Featured
Chemical Structure
444606-18-2
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Field of application
Dilmapimod, also known as SB-681323 and GW-681323 , is p38 MAPK inhibitor. SB-681323 inhibited the p38 MAPK pathway to a greater degree than prednisolone did. SB-681323 inhibited TNF-alpha production. SB-681323 is a potent p38 MAPK inhibitor that potentia
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 444606-18-2
Chemical Name: Dilmapimod
Synonyms: SB681323; SB 681323; SB-681323; GW 681323; GW-681323; GW681323; Dilmapimod.
SMILES: O=C1N(C2C(F)=CC=CC=2F)C2C(=C(N=C(N=2)NC(CO)CO)C2C(C)=CC(F)=CC=2)C=C1
Formula: C23H19F3N4O3
M.Wt: 456.42
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Singh D, et al. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol. 2010 Jan;50(1):94-100.
Description: Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.
In Vitro: Dilmapimod (SB-681323) potently inhibits p38 MAPK signaling, measured by inhibition of sorbitol-induced pHSP27 expression[1].
MSDS
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COA
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