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SBI-553

  Cat. No.:  DC26198   Featured
Chemical Structure
1849603-72-0
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More than 5000 active chemicals with high quality for research!
Field of application
SBI-553 is a potent and brain penetrant NTR1 allosteric modulator with EC50 of 0.34μM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1849603-72-0
Chemical Name: 2-((2-(1-Fluorocyclopropyl)-4-(4-(2-methoxyphenyl)piperidin-1-yl)quinazolin-6-yl)(methyl)amino)ethan-1-ol
Synonyms: SBI-553; SBI 553; SBI553
SMILES: OCCN(C)C1C=CC2C(=C(N=C(N=2)C2(CC2)F)N2CCC(C3C(OC)=CC=CC=3)CC2)C=1
Formula: C26H31FN4O2
M.Wt: 450.55
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Publication: 1: Pinkerton AB, Peddibhotla S, Yamamoto F, Slosky LM, Bai Y, Maloney P, Hershberger P, Hedrick MP, Falter B, Ardecky RJ, Smith LH, Chung TDY, Jackson MR, Caron MG, Barak LS. Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. J Med Chem. 2019 Aug 20. doi: 10.1021/acs.jmedchem.9b00340. [Epub ahead of print] PubMed PMID: 31390201.
Description: SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM[1].
Target: EC50: 0.34 μM (NTR1)[1].
References: [1]. Pinkerton AB, et al. Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. J Med Chem. 2019 Aug 20.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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