ST-271|ST271||PLD inhibitor

Cas No.:	106392-48-7
Chemical Name:	2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)-
Synonyms:	ST271,ST 271,ST-271
SMILES:	CC(C)C1=CC(=CC(=C1O)C(C)C)/C=C(\C#N)/C(=O)N
Formula:	C₁₆H₁₉N₂O₂
M.Wt:	272.34
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	ST271 is a potent inhibitor of protein tyrosine kinase (PTK).
In Vitro:	ST271 partially inhibits peptide phosphorylation in the membrane preparation and in permeabilized platelets[1]. ST271 (100 μM) causes complete inhibition of formation of inositol phosphates induced by FcγRII cross-linking, but also induces a small (< 30%) but significant inhibition of the response to thrombin and U46619[2].
References:	[1]. Martinson EA, et al. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors. Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):627-34. [2]. Blake RA, et al. Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor.

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